Most lifters, especially bodybuilders, are familiar with drop sets: Lift a weight to failure or close to it, drop some weight and continue the set without resting, hit failure, drop more weight, crank out more reps, etc.
This descending method for hypertrophy is effective, but I also like to use ascending sets. This is when you add weight instead of taking it off. Here's how I use that method on the leg press.
Not only does this increase time under tension, you're also working heavy and building strength.