How does training with weights change your body?

Your high school PE teacher – back when schools still made physical education part of the curriculum – likely offered the classic "house in the hurricane analogy."

"Training affects your muscles like a minor hurricane does a house. It cracks windows, rips off shingles, and busts up the fence. But if you don't overdo it, and give your body the materials (food) and the time to rest and make repairs, it will come back bigger and stronger than before."

Sadly, even your eighth-grade self knew this was way too simplistic, but you didn't press the matter. You knew better than to lock horns with an overly caffeinated gym teacher armed with a whistle.

Fact is, strength training does more than just create muscle damage. It releases a variety of hormones that also influence how you'll adapt and grow from your training session.

What many trainees don't know is how to manipulate this hormonal cascade to get bigger, stronger, and leaner. Is there an ideal way to structure your training to get the most out of your hormonal environment?

Research findings, in combination with anecdotal evidence from the training floor, suggest that it is possible. While many hormones come into play during resistance training, the four major ones are Testosterone, growth hormone (GH), insulin-like growth factor (IGF), and cortisol. These are the most researched hormones in relation to strength training, and the science supporting their role in the process appears solid.


No hormone gets as much press in strength training as the capital T and for good reason. Testosterone has an important role in the signaling of protein synthesis and reduces the impact of catabolic hormones.

It's lesser known, but no less important role is as a facilitator for other hormonal mechanisms such as growth hormone and IGF-1 in the anabolic process (1).

Simply stated, Testosterone is anabolic on its own and makes other hormones more anabolic just by showing up.

Although there are several factors that stimulate elevations in Testosterone, it appears that exercise selection may be the key variable. Large, compound exercises such as the Olympic lifts (2), deadlifts (3), and jump squats have been shown to produce large elevations in Testosterone as compared to small-mass exercises (4, 5).

Research also supports that sequencing these movements properly is critical. Large muscle-mass, multi-joint movements placed early in the program tend to increase strength and lead to elevated Testosterone levels throughout the workout.

Growth Hormone

The main function of growth hormone is in promoting tissue anabolism. So if you want muscle cells to increase in size, GH is a key factor.

Research shows that strength protocols that elicit high levels of blood lactate tend to produce the most substantial GH responses (6, 7, 8, 9, 10). Lactate training is often affiliated with the common parameters of hypertrophy training.

So protocols that are relatively high in intensity (75% of 1RM), high volume, use large amounts of muscle mass, and have relatively short rest periods tend to get GH flowing.

It's also worth noting that much of GH is released at night during sleep. So getting an appropriate amount of sleep and recovery is critical to maximize its effects.

IGF (Insulin-Like Growth Factor)

The job of IGF is to mediate the many actions of growth hormone. An analogy may help: if GH is you in a Las Vegas strip club, IGF is like a huge stack of dollar bills.

Another way to look at it is, if insulin is the key hormone used to signal glucose to enter a cell, IGF works in a similar way for GH. IGF also aids in protein synthesis during strength training and therefore enhance hypertrophy (11).

Since IGF's main job is to work concurrently with GH, similar resistance training protocols as above should be followed to maximize this hormone's effects.


As opposed to the hormones discussed earlier, cortisol is actually catabolic in nature. What that means is that this stress-response hormone breaks down tissue. So rather than trying to maximize its response, we're going to try to minimize it.

The best way to shunt the cortisol response from training is likely through nutritional interventions, specifically an insulin-spiking post-workout shake such as Surge® Recovery, or a pre and intra-workout drink like Plazma™. Training factors can also come into play.

Cortisol spikes during very metabolically demanding training protocols that are high in total volume with very short rest periods. However, typical strength and power training parameters tend to have little to no effect on cortisol. This is certainly something to account for when designing your program.

Interestingly, as cortisol is catabolic, it does stimulate lypolysis of adipose tissue (breakdown of fats), so if you're training exclusively for fat loss, spiking cortisol may be a good thing.

Just remember, it's a fine line between fat breakdown and muscle breakdown, so if you over do the metabolic training, you may end up with some muscle loss to accompany your lower body fat.

Here's a quick review:

  • Testosterone, growth hormone, and IGF are major anabolic hormones that can be manipulated to a degree through specific training variables.
  • Optimal strength and hypertrophy training parameters tend to maximize the benefits of the anabolic hormones.
  • Cortisol is a catabolic hormone that's released mainly during very metabolically demanding training with short rest periods. Therefore, its effect should be managed.

To take advantage of the hormonal environment that can be manipulated through resistance training, I've designed the program below.

You can either follow the exercise selections below or substitute your own, but the critical factors are as follows:

  • The first movement should always be a multi-joint, big "bang-for-your-buck" exercise. You'll be training that movement with an emphasis on strength (85%+ of 1RM for 6 sets of 3 reps).
  • Subsequent movements will mainly be compound as well, but will use significantly less load and fall within the training parameters normally associated with hypertrophy (70-80% of 1RM with 3-4 sets of 8-12 reps).
  • Even if you do substitute different exercises, make sure to keep the reps, sets, and rest periods the same as prescribed. Otherwise you're not going to get the desired effect.
  • This is designed as a four-day workout. Ideally, you'll train Monday, Tuesday, Thursday, and Friday. We'll have two upper body days and two lower body days.
  • If you're training three days per week or less, consider making every training session total body to insure that you're getting enough training volume on all the major muscle groups.
  • Tempo is another important factor in getting the proper training effect so don't ignore it. It's prescribed in the training program below.

Day One (Monday)

  Exercise Sets Reps Tempo Rest
A Front Squat 6 3 3010 2 min.
B1 Bulgarian Split Squat * 4 8-10 2110 1 min.
B2 Romanian Deadlift 4 8-10 3010 1 min.
C1 Leg Press 3 10-12 3010 50 sec.
C2 Farmers Walk * * 3 10-12 3010 50 sec.

* Bulgarian Split Squat – per side
* * Farmers Walk – steps per side

Day 2 (Tuesday)

  Exercise Sets Reps Tempo Rest
A Weighted Chin-Up 6 3 3010 2 min.
B1 Flat Dumbbell Bench Press 4 8-10 3010 1 min.
B2 Single-Arm Dumbbell Row * 4 8-10 2011 1 min.
C1 Decline Push-Ups 3 10-12 3010 50 sec.
C2 Seated Cable Row 3 10-12 2011 50 sec.

* Single-Arm Dumbbell Row – per side

Wednesday: Rest

Day 3 (Thursday)

  Exercise Sets Reps Tempo Rest
A Clean-Grip Deadlift 6 3 2010 2 min.
B1 Leg Extension 4 8-10 2011 1 min.
B2 Single-Leg Hamstring Curl * 4 8-10 40X0 1 min.
C1 Glute Ham Raise 3 10-12 30X0 50 sec.
C2 Seated Calf Raise 3 10-12 3011 50 sec.

* Single-Leg Hamstring Curl – per side

Day 4 (Friday)

  Exercise Sets Reps Tempo Rest
A Incline Barbell Bench Press 6 3 3010 2 min.
B1 Neutral Grip Pull-Up or Pulldowns 4 8-10 3010 1 min.
B2 Single-Arm Standing Overhead Dumbbell Press * 4 8-10 3010 1 min.
C1 Face Pulls 3 10-12 2011 50 sec.
C2 Cable Chest Flye 3 10-12 3011 50 sec.

* Single-Arm Standing Overhead Dumbbell Press – per side

Saturday and Sunday: Rest

You'll see every session starts with a major compound movement using a rep/set scheme that emphasizes strength (for the Testosterone response).

Next up are the multi-joint movements with a focus on hypertrophy – keeping volume high and rest fairly low (the key components to maximize GH and IGF), but not so little rest that we train too metabolically (to keep the cortisol response as minimal as possible).

It's also worth noting that this program focuses on strength and hypertrophy, as attacking those two goals is an ideal way to improve body composition. However, if fat loss were the sole purpose of your training the entire program would have to change, but that's the subject for a follow-up article.

This program has yielded excellent results with many clients and colleagues who've tried it – to what degree is due to modulating hormones or simply from a general training effect is open to debate.

I just know that it works, reliably and consistently.

Granted, any training program that uses challenging loads will have some effect on the hormonal system, but "some" effect and "optimal" effect are two different things. If you maximize the effect of these major hormonal players you're sure to be one step closer to a body composition that stands out.

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  2. Kraemer WJ et al. Acute hormonal responses in elite junior weightlifters. Int J Sports Med. 1992 Feb;13(2):103-9. PubMed.
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  9. Kraemer WJ et al. The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery. J Strength Cond Res. 2003 Aug;17(3):455-62. PubMed.
  10. Hoffman JR et al. Effect of muscle oxygenation during resistance exercise on anabolic hormone response. Med Sci Sports Exerc. 2003 Nov;35(11):1929-34. PubMed.
  11. Kahn SM et al. Sex hormone-binding globulin is synthesized in target cells. J Endocrinol. 2002 Oct;175(1):113-20. PubMed.