If obesity is a disease of inflammation, resveratrol is one key piece of the anti-inflammatory puzzle.

Several lines of clinical evidence in human tissue explants have shown that resveratrol has potent anti-inflammatory effects on fat cells.

Specifically, resveratrol downregulates the secretion and gene expression of several harmful adipokines (IL6, IL8 and monocyte chemoattractant protein 1) and also decreases fat storage.


  1. Olholm J, Paulsen SK, Cullberg KB, Richelsen B, Pedersen SB. Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants. Int J Obes (Lond). 2010 Jun 8.[Epub ahead of print]
  2. Fischer-Posovszky P, Kukulus V, Tews D, Unterkircher T, Debatin KM, Fulda S, Wabitsch M. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr. 2010 Jul;92(1):5-15. Epub 2010 May 12.