If obesity is a disease of inflammation, resveratrol is one key piece of the anti-inflammatory puzzle.
Several lines of clinical evidence in human tissue explants have shown that resveratrol has potent anti-inflammatory effects on fat cells.
Specifically, resveratrol downregulates the secretion and gene expression of several harmful adipokines (IL6, IL8 and monocyte chemoattractant protein 1) and also decreases fat storage.
- Olholm J, Paulsen SK, Cullberg KB, Richelsen B, Pedersen SB. Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants. Int J Obes (Lond). 2010 Jun 8.[Epub ahead of print]
- Fischer-Posovszky P, Kukulus V, Tews D, Unterkircher T, Debatin KM, Fulda S, Wabitsch M. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr. 2010 Jul;92(1):5-15. Epub 2010 May 12.