Maximizes the Anabolic Effects of
Insulin and Testosterone
Let's assume for a moment that you're all-powerful; not all-powerful like, say, Donald Trump or Oprah, but better in that you're able to manipulate time, space, and even cellular machinery.
As an all-powerful person, you'd want to look the part, so you'd do the alakazam, presto-chango bit and probably do 2 or 3 things to your cellular machinery that would allow your body to grow super big and super lean.
First, you'd probably alter muscle-fiber properties so that your slow-twitch fibers (the "endurance" fibers that you find in high concentrations in marathon runners) became more like fast-twitch fibers (the kind you find in high concentrations in sprinters, powerlifters, and accomplished bodybuilders).
That way, the basic architecture of your muscles would allow for "bigness."
Secondly, you'd want to alter the sensitivity of your insulin receptors, making them as sensitive as possible to the effects of what some people call "the most anabolic hormone of all," insulin.
Manipulating insulin to your advantage would have a huge nutrient-partitioning effect, driving food (and stored food energy) into building muscle instead of building fat.
Thirdly, you'd want to increase the number of androgen receptors in muscle. Adding more androgen receptors would give more sites for Testosterone to bind to, which would mean increased muscle growth independent of changes in your natural levels of Testosterone.
Being able to do those three things would be terrific, wouldn't it?
Well, consider yourself all-powerful because now you can do all three of those things with Receptormax,TM BIOTEST's latest and greatest ground-breaking supplement.
Increases the sensitivity of insulin receptors;
Increases the number of androgen receptors; and even
Makes slow twitch, growth-resistant muscle fibers act more like fast twitch, growth-anxious muscle fibers.
How'd we do it?
By combining 5 heavily researched, naturally occurring compounds that, in addition to building muscle and dumping body fat, have a long list of secondary healthful benefits (most of which will be the subject of another article).
Cinnamomum burmanni (water extract, standardized for type-A polymers, tetramers, and trimers)
Na (sodium) R-alpha-lipoic acid
Let's take a look at the research behind these individual ingredients and examine how they can create a lean and very muscular body.
Acetyl-L-Carnitine Increases Androgen Receptors
Renowned muscle researcher Dr. Bill Kraemer has published a handful of excellent studies showing that the acetylated form of L-Carnitine increases androgen receptor content following whole-body resistance training workouts.(1)
Kraemer showed that 21 days of supplementation with acetyl-L-carnitine led to a significant increase in the androgen-receptor content of the vastus lateralis muscle in the thigh. (The vastus lateralis is the traditional spot from which to take muscle biopsies and if the number of androgen receptors increased there, they increased in all muscles.)
Additionally, Kraemer noted that the athletes' blood levels of Testosterone plummeted after a workout. While that initially sounds like a bad thing, it's not. Instead, it shows that something good happened.
Since the "roads" (blood vessels) had less Testosterone flowing through them, it meant that Testosterone had pulled off the road and "parked" in the new Testosterone receptors found on the acetyl-L-carnitine user's muscle.
Since there were more parking spots for Testosterone to park, it leads to more protein synthesis, which literally means more muscle.
Furthermore, the temporarily low level of free Testosterone in the blood stream tells the brain (the pituitary-gonadal axis), through negative feedback, that it needs to start producing even more Testosterone.
So you get a double bonus: More T is attached to muscles and more T is produced.
Another acetyl-L-carnitine study by Volek and Kraemer showed that athletes who used the compound after a squat workout had increased recovery. This is due probably not only to the effects mentioned in the previous study, but due to fewer markers of inflammation via an increase in blood flow, oxygen delivery, and regeneration of ATP, the energy substrate of the cell.(2)
Clearly, the discovery that acetyl-L-carnitine increases the androgen-receptor content of muscle is a huge deal.
But what about the other all-powerful receptor site? What about insulin receptors?
Cinnamomum Burmanni Increases Insulin Sensitivity
In a study of 49 herbs, spices, and medicinal plants known to affect insulin, good ol' common cinnamon was shown to have the most insulin activity.(3)
Before I go on, you have to understand that we didn't just steal momma's cinnamon from her spice rack. Instead, we used a high grade, water-soluble extract, standardized for the active fractions of the spice. Sure there are other, less-expensive forms of cinnamon available, but they aren't standardized for the active fractions. And if a cinnamon extract contain the fat-soluble portion of cinnamon, it may actually become toxic over time.
So what effect does Cinnamomum burmanni have in the body?
Numerous studies have shown it to improve the metabolic action of insulin resistance by increasing glucose uptake by the cells and enhancing the insulin-signaling pathway in muscle.(4)
In one study, it reduced the fasting plasma glucose levels of patients with full-blown Type 2 diabetes by 10.3%.(5)
Another study of 60 women with Type 2 Diabetes showed a decrease of fasting glucose levels of 29%, which is an incredible increase in insulin sensitivity and all the more impressive because the patients were diabetic.(6)
A third study showed that cinnamon extract given to 21 adults with pre-diabetes led to a 1.1% increase in muscle mass and a 0.7% decrease in body fat, without exercise.(7)
Clearly, Cinnamomum burmanni extract improves insulin sensitivity, but why is that important?
Well, for muscleheads, insulin is a hormone that must be manipulated, regardless of your body type. For those trying to gain muscle mass, insulin sensitivity must be high and spiking insulin can provide a tremendous amount of anti-catabolic effects. This can lead to large increases in muscle mass, and this is one of the reasons why kamikaze pro bodybuilders sometimes inject insulin.
Secondly, if you're insulin resistant (your "parking spots" won't accept insulin), you can end up storing a tremendous amount of body fat. At the very least, you'd find it really difficult to get lean and impossible to get shredded.
Lastly, not only can insulin affect this golden pair of physique goals (muscle gain and fat loss), but it can also affect just about every other hormone in the body, including Testosterone.
It should be clear that having cellular receptors that are extremely sensitive to insulin is extremely important, and the more you can do to improve this sensitivity, through numerous mechanisms, the better.
4-Hydroxyisoleucine Regulates Insulin Secretion
4-Hydroxyisoleucine is an amino acid derived from fenugreek seeds. It activates both insulin signaling and insulin secretion. As such, it's useful in enhancing uptake of anabolic nutrients (including other ReceptormaxTM ingredients like CoQ10 and acetyl-L-carnitine), along with possibly regenerating muscle glycogen.(8)
A noteworthy aspect of 4-hydroxyisoleucine is that its effects are glucose dependent. As glucose increases, so does the insulin-promoting response elicited by 4-hydroxyisoleucine.
That means that the supplement regulates the insulin needs of the body at any given time.
As such, medical researchers are hugely interested in this compound and its effects on the two essential dysfunctions of Type 2 diabetes. Accordingly, 4-hydroxyisoleucine is regarded as the potential leader of a new class of anti-diabetic agents.(9)
While you're presumably not diabetic, this is simply further evidence that 4-hydroxyisoleucine allows the physique athlete to manipulate insulin to his advantage.
Na R-Alpha-Lipoic Acid Increases Glucose Uptake in Insulin-Resistant Cells
While many nutritionists regard alpha-lipoic acid as a vitamin, it's actually a coenzyme.
It's generally regarded as one of the most-potent antioxidants, not only because of its impressive redox potential, but also because it's soluble in both fat and water. This allows it to do its good work in all parts of the body.
But that's not why we included a type of alpha-lipoic acid in the ReceptormaxTM formula. In addition to all of these healthful benefits, alpha-lipoic acid helps increase glucose uptake in insulin-resistant cells.(10, 11, 12)
(Remember, the more you're able to control insulin, the better you're able to shape your body to your specifications.)
Na R-alpha-lipoic acid (Na R-ALA) also has a nice synergy with two other ingredients found in Receptormax.TM In conjunction with acetyl-L-carnitine, Na R-ALA reverses mitochondrial decay and actually restores mitochondrial function to youthful levels.(13) (Mitochondria are the tiny cellular organelles that produce ATP, which is the "currency" of metabolism.)
Na R-ALA also amplifies the effects of another one of the ingredients in Receptormax,TM Coenzyme Q10, making for a very, very, nice synergy.
While generic alpha-lipoic acid is an impressive supplement all on its own, ReceptormaxTM uses Na R-alpha-lipoic acid, which is quite rightly regarded as the "next generation" lipoic acid. Maximum plasma levels of Na R-ALA are 30 times higher than pure R-alpha-Lipoic acid.(14)
Coenzyme Q10 Increases Fast-Twitch Fiber Makeup
CoQ10 is a vitamin like, fat-soluble compound that's found in all cells of the body. It's intimately involved in the formation of ATP, acts as an essential antioxidant, influences the stability, fluidity, and permeability of cell membranes, and has beneficial effects on cell signaling and gene expression.
However, none of that has much to do with why CoQ10 is included in Receptormax.TM
CoQ10 is unique, almost magical, in that 300 mg per day actually alters fiber properties so that slow-twitch muscle fibers (the ones most resistant to hypertrophy) actually become more like fast-twitch muscle fibers (the ones that hypertrophy easily).(15)
Additionally, 2 to 3 studies have shown that CoQ10 improved aerobic power, anaerobic threshold, and time to exhaustion.
How to Use ReceptormaxTM
Receptormax is one of those easy-to-use supplements that doesn't require cycling. In addition to making the body more sensitive to insulin, increasing the androgen receptor content of muscles, and making slow twitch, growth-resistant muscle fibers act like fast twitch, fast-growing muscle fibers, it also has a ton of healthful benefits.
Anyone, man or woman, interested in building their body, losing fat, or just being healthier, should use Receptormax.TM
Just take 6 capsules a day.
Non-Training Days: Take 2 capsules a half-hour before each of 3 meals (ideally, evenly space meals).
EXAMPLE: Take 2 capsules a half-hour before breakfast, 2 capsules a half-hour before dinner, and 2 capsules a half-hour before your bedtime snack.
Training Days: Take 3 capsules a half-hour before you train, and 1 capsule a half-hour before each of 3 meals.
EXAMPLE: Take 1 capsule a half-hour before breakfast, 1 capsule a half-hour before lunch, 3 capsules a half-hour before your workout, and 1 capsule a half-hour before your bedtime snack.
The Power of ReceptormaxTM
Ever since the first batch of ReceptormaxTM arrived in the warehouse (about two weeks ago), I've been anxiously telling all my friends and family members about it. I want them all to be on ReceptormaxTM immediately! That's how much I believe in this formula.
If you control insulin, if you can maximize Testosterone receptor content, if you can actually make slow twitch, growth-resistant muscle fibers act more like fast twitch, fast-growing muscle fibers, then you practically are all-powerful.
1. Kraemer, William J. et al. Androgenic Responses to Resistance Exercise: Effects of Feeding and L-Carnitine. Med Sci Sports Exerc. Vol. 38, No. 7, pp. 1288-96.
2. Volek, Jeff S., Kraemer, Wiliam J., et al. L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. Am J Physio Endocrinol Metab 282: E474-E482, 2002.
3. Broadhurst CL, et al. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. Journal of Agricultural and Food Chemistry 2000 48:849-852.
4. Qin, B, et al. Cinnamon extract potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabetes Research and Clinical Practice 2003 62:139-148.
5. Mang, B, et al. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest 2006:36;340-344.
6. Kim, SH, et al. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. Journal of Endocrinology 206 104:119-123.
7. Ziegenfuss, TN, et al. Effects of a proprietary water-soluble extract on metabolic syndrome. Diabetes Care, 2006.
8. Ruby, BC, et al. The addition of fenugreek extract to glucose feeding increases muscle glycogen resynthesis after exercise. Amino Acids 2005, Feb;28(1):71-76.
9. Broca, Christophe, et al. Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat. Am J Physiol Endocrinol Metab 287: E463-E471, 2004.
10. Jacob, S. et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzeneimittelforschung. 1995 Aug;45(8):872-4.
11. Konrad, T, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care. 1999 Feb;22(2):280-7.
12. Estrada, DE, et al. Stimulation of glucose uptake by natural coenzyme alpha-lipoic acid/thotic acid: participation of elements of the insulin signaling pathway. Diabetes. 1996 Dec;4(12):1798-804.
13. Jose Antonio. Reducing Aging Markers with Lipoic Acid. LE Magazine. June 2008.
14. Carlson, DA, et al. An evaluation of the stability and plasma pharmokinetics of R-lipoic acid and R-dihydrolipoic acid dosage forms in healthy human plasma from healthy subjects. Packer L, Patel M, eds. Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects. London, England: Taylor & Francis Publishers; 2008:235-70.
15. Linnane, Anthony, et al. Cellular Redox Activity of Coenzyme Q10: Effect of CoQ10 Supplementation on Human Skeletal Muscle. Free Radical Research, 2002 Vol. 36 (4), pp. 445-453.